![]() ![]() ![]() In Korea, the first case of the HIV infection was reported in 1985, and more than 1000 new infections have occurred every year in the last 5 years. Early confirmatory diagnosis can prevent secondary transmission of HIV and provide early treatment opportunities for people living with HIV infection. The new testing algorithm has improved the diagnosis of HIV infections in the early acute stage. Of positive cases reported by the KDCA, 22.9% were in the early acute stage and Fiebig stages I to II. The results for the p31 reactive band were 27.4% and 88.4% for the KDCA and PIHEs, respectively. However, the number of indeterminate cases dropped sharply, from 71.9% in 2014 to 14.0% in 2017. The number of positive cases in the samples requested from PIHEs for reconfirmation by the KDCA has steadily increased from 10.3% in 2014 to 33.3% in 2017. Fiebig stages and Western blot p31 band were used to identify the diagnostic proportions of acute or early chronic HIV for the two algorithms. Our study aimed to investigate the effect of this new testing algorithm on the confirmation rate of HIV infection.Īnnual changes, from 2012 through 2017, in positive or indeterminate HIV confirmatory results were compared for the two algorithms between the PIHEs and the KDCA. The Korea Disease Control and Prevention Agency (KDCA) has further included p24 antigen neutralization and nucleic acid tests (NATs) since 2015. The 17 Provincial Institutes of Health and Environment (PIHEs) in Korea use HIV antibody, antigen, and Western blot assays for confirmatory testing of HIV infection. ![]()
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